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Magic™ Membrane Protein Human ATP6V0A1 (ATPase H+ transporting V0 subunit a1) Full Length (CAT#: MPC0412K) Made to Order

Datasheet
This product is a 96.4 kDa Human ATP6V0A1 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ATP6V0A1
  • Protein Length
  • Full length
  • Protein Class
  • Transporter; Ion Transporter
  • Molecular Weight
  • 96.4 kDa
  • TMD
  • 8
  • Sequence
  • MGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRK
    FVNEVRRCEEMDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEAN
    FEKIENELKEINTNQEALKRNFLELTELKFILRKTQQFFDEMADPDLLEE
    SSSLLEPSEMGRGTPLRLGFVAGVINRERIPTFERMLWRVCRGNVFLRQA
    EIENPLEDPVTGDYVHKSVFIIFFQGDQLKNRVKKICEGFRASLYPCPET
    PQERKEMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFIKVRKM
    KAIYHTLNLCNIDVTQKCLIAEVWCPVTDLDSIQFALRRGTEHSGSTVPS
    ILNRMQTNQTPPTYNKTNKFTYGFQNIVDAYGIGTYREINPAPYTIITFP
    FLFAVMFGDFGHGILMTLFAVWMVLRESRILSQKNENEMFSTVFSGRYII
    LLMGVFSMYTGLIYNDCFSKSLNIFGSSWSVRPMFTYNWTEETLRGNPVL
    QLNPALPGVFGGPYPFGIDPIWNIATNKLTFLNSFKMKMSVILGIIHMLF
    GVSLSLFNHIYFKKPLNIYFGFIPEIIFMTSLFGYLVILIFYKWTAYDAH
    TSENAPSLLIHFINMFLFSYPESGYSMLYSGQKGIQCFLVVVALLCVPWM
    LLFKPLVLRRQYLRRKHLGTLNFGGIRVGNGPTEEDAEIIQHDQLSTHSE
    DADEPSEDEVFDFGDTMVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQ
    LSEVLWTMVIHIGLSVKSLAGGLVLFFFFTAFATLTVAILLIMEGLSAFL
    HALRLHWVEFQNKFYSGTGFKFLPFSFEHIREGKFEE

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • ATP6V0A1
  • Full Name
  • ATPase H+ transporting V0 subunit a1
  • Introduction
  • This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene.
  • Alternative Names
  • a1; Stv1; VPP1; Vph1; ATP6N1; ATP6N1A; V-type proton ATPase 116 kDa subunit a1; ATPase, H+ transporting, lysosomal V0 subunit a1; ATPase, H+ transporting, lysosomal non-catalytic accessory protein 1 (110/116kD); H(+)-transporting two-sector ATPase, 116 kDa accessory protein A1; V-ATPase 116 kDa subunit a1; V-type proton ATPase 116 kDa subunit a; clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit; vacuolar adenosine triphosphatase subunit Ac116; vacuolar proton pump subunit 1; vacuolar proton translocating ATPase 116 kDa subunit A; vacuolar-type H(+)-ATPase 115 kDa subunit; ATP6V0A1; ATPase H+ transporting V0 subunit a1

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