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Magic™ Membrane Protein Human BACE2 (Beta-secretase 2) Full Length (CAT#: MPC1628K) Made to Order

Datasheet
This product is a 56.1 kDa Human BACE2 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • BACE2
  • Protein Length
  • Full length
  • Protein Class
  • Protease
  • Molecular Weight
  • 56.1 kDa
  • TMD
  • 1
  • Sequence
  • MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPG
    TPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGT
    PPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYT
    QGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLA
    YATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLV
    LGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKA
    IVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSET
    PWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISP
    STNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFST
    EDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRP
    RDPEVVNDESSLVRHRWK

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • BACE2
  • Full Name
  • Beta-secretase 2
  • Introduction
  • This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • BACE2; ASP1; BAE2; DRAP; AEPLC; ALP56; ASP21; CDA13; CEAP1; 56 kDa aspartic-like protease; Down syndrome region aspartic protease; SLCO3A1/BACE2 fusion; aspartyl protease 1; beta-site APP-cleaving enzyme 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2; memapsin-1; membrane-associated aspartic protease 1; theta-secretase; transmembrane aspartic proteinase Asp1; Beta-secretase 2

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