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Magic™ Membrane Protein Human CLCN4 (Chloride voltage-gated channel 4) Full Length (CAT#: MPC0483K) Made to Order

Datasheet
This product is a 84.9 kDa Human CLCN4 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CLCN4
  • Protein Length
  • Full length
  • Protein Class
  • Transporter; Ion channel
  • Molecular Weight
  • 84.9 kDa
  • TMD
  • 15
  • Sequence
  • MVNAGAMSGSGNLMDFLDEPFPDVGTYEDFHTIDWLREKSRDTDRHRKIT
    SKSKESIWEFIKSLLDAWSGWVVMLLIGLLAGTLAGVIDLAVDWMTDLKE
    GVCLSAFWYSHEQCCWTSNETTFEDRDKCPLWQKWSELLVNQSEGASAYI
    LNYLMYILWALLFAFLAVSLVRVFAPYACGSGIPEIKTILSGFIIRGYLG
    KWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCGNFFSSLFSKYSKNEG
    KRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALV
    AAFTLRSINPFGNSRLVLFYVEYHTPWYMAELFPFILLGVFGGLWGTLFI
    RCNIAWCRRRKTTRLGKYPVLEVIVVTAITAIIAYPNPYTRQSTSELISE
    LFNDCGALESSQLCDYINDPNMTRPVDDIPDRPAGVGVYTAMWQLALALI
    FKIVVTIFTFGMKIPSGLFIPSMAVGAIAGRMVGIGVEQLAYHHHDWIIF
    RNWCRPGADCVTPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIV
    PLMAAAVTSKWVADAFGKEGIYEAHIHLNGYPFLDVKDEFTHRTLATDVM
    RPRRGEPPLSVLTQDSMTVEDVETLIKETDYNGFPVVVSRDSERLIGFAQ
    RRELILAIKNARQRQEGIVSNSIMYFTEEPPELPANSPHPLKLRRILNLS
    PFTVTDHTPMETVVDIFRKLGLRQCLVTRSGRLLGIITKKDVLRHMAQMA
    NQDPESIMFN

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • CLCN4
  • Full Name
  • Chloride voltage-gated channel 4
  • Introduction
  • The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins.
  • Alternative Names
  • CLC4; ClC-4; MRX15; MRX49; ClC-4A; MRXSRC; H(+)/Cl(-) exchange transporter 4; chloride channel 4; chloride channel protein 4; chloride channel, voltage-sensitive 4; chloride transporter ClC-4; CLCN4; Chloride voltage-gated channel 4

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