Close
Close

Magic™ Membrane Protein Human CXCR4 (C-X-C motif chemokine receptor 4) (CAT#: MP0010F)

Datasheet
Human CXCR4 (C-X-C Chemokine Receptor type 4) is an α-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes. CXCR4 is essential for proper fetal development and is the major co-receptor for T-tropic strains of human immunodeficiency virus 1 (HIV-1). Additionally, SDF-1 and CXCR4 mediate cancer cell migration and metastasis. As most N-terminal domain of chemokine receptors are the ligand binding domain, the N-terminal domain of CXCR4 is the binding site for SDF-1.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CXCR4
  • Protein Length
  • Full Length
  • Protein Class
  • Receptor
  • Molecular Weight
  • 43 kDa
  • TMD
  • 7
  • Sequence
  • MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVI
    LVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNL
    YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEA
    DDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKT
    TVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPI
    LYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS

Product Description

  • Activity
  • Validated
  • Application
  • Screening & display technologies
  • Expression Systems
  • Cell-free expression system in the presence of lipid vesicles
  • Tag
  • Histidine tag fused to the N-terminal end of the protein
  • Protein Format
  • Proteoliposome
  • Purification
  • Sucrose gradient
  • Purity
  • >70% by SDS-Page and Coomassie Blue staining
  • Buffer
  • Tris 50mM, pH 7.5

Target

  • Target Protein
  • CXCR4
  • Full Name
  • C-X-C motif chemokine receptor 4
  • Introduction
  • This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
  • Alternative Names
  • FB22, HM89, LAP3, LCR1, NPYR, WHIM, CD184, LAP-3, LESTR, NPY3R, NPYRL, WHIMS, HSY3RR, NPYY3R, D2S201E

Customer reviews and Q&As    

Q&As

What is the role of CXCR4 in vivo?

During the early stages of development, SDF-1 and CXCR4 play a role in cell migration. Throughout life, especially in adulthood, SDF-1/CXCR4 signaling may influence stem cell migration from bone marrow or niches to repair damaged tissues. Increased numbers of CXCR4 cells may be associated with inflammation/normal stem cell migration and cancer/malignancy abnormalities.
2022-12-17

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

Related Products
Online Inquiry
CONTACT US
USA:
Europe:
Germany:
Call us at:
USA:
UK:
Germany:
Fax:
Email:
Our customer service representatives are available 24 hours a day, 7 days a week. Contact Us
© 2024 Creative Biolabs. | Contact Us