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Magic™ Membrane Protein Human CYP7B1 (Cytochrome P450 family 7 subfamily B member 1) Full Length (CAT#: MPC4723K) Made to Order

Datasheet
This product is a made-to-order Human CYP7B1 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CYP7B1
  • Protein Length
  • Full length
  • Protein Class
  • Oxidoreductase
  • TMD
  • 2
  • Sequence
  • MAGEVSAATGRFSLERLGLPGLALAAALLLLALCLLVRRTRRPGEPPLIK
    GWLPYLGVVLNLRKDPLRFMKTLQKQHGDTFTVLLGGKYITFILDPFQYQ
    LVIKNHKQLSFRVFSNKLLEKAFSISQLQKNHDMNDELHLCYQFLQGKSL
    DILLESMMQNLKQVFEPQLLKTTSWDTAELYPFCSSIIFEITFTTIYGKV
    IVCDNNKFISELRDDFLKFDDKFAYLVSNIPIELLGNVKSIREKIIKCFS
    SEKLAKMQGWSEVFQSRQDVLEKYYVHEDLEIGAHHLGFLWASVANTIPT
    MFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIHLTREQLDSLI
    CLESSIFEALRLSSYSTTIRFVEEDLTLSSETGDYCVRKGDLVAIFPPVL
    HGDPEIFEAPEEFRYDRFIEDGKKKTTFFKRGKKLKCYLMPFGTGTSKCP
    GRFFALMEIKQLLVILLTYFDLEIIDDKPIGLNYSRLLFGIQYPDSDVLF
    RYKVKS

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements (Detergent, Liposome, Nanodisc, SMALPs, VLP)

Target

  • Target Protein
  • CYP7B1
  • Full Name
  • Cytochrome P450 family 7 subfamily B member 1
  • Introduction
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme likely plays a minor role in total bile acid synthesis, but may also be involved in the development of atherosclerosis, neurosteroid metabolism and sex hormone synthesis. Mutations in this gene have been associated with hereditary spastic paraplegia (SPG5 or HSP), an autosomal recessive disorder.
  • Alternative Names
  • CYP7B1; CP7B; CBAS3; SPG5A; cytochrome P450 7B1; 24-hydroxycholesterol 7-alpha-hydroxylase; 25-hydroxycholesterol 7-alpha-hydroxylase; 25/26-hydroxycholesterol 7-alpha-hydroxylase; 3-hydroxysteroid 7-alpha hydroxylase; cytochrome P450, subfamily VIIB (oxysterol 7 alpha-hydroxylase), polypeptide 1; oxysterol 7-alpha-hydroxylase; Cytochrome P450 family 7 subfamily B member 1

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