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Magic™ Membrane Protein Human GABRA5 (Gamma-aminobutyric acid type A receptor subunit alpha5) expressed in HEK293T for Antibody Discovery (CAT#: MP1267J)

Datasheet
This product is a 48.6 kDa Human GABRA5 membrane protein expressed in HEK293T. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • GABRA5
  • Protein Length
  • Full-length
  • Protein Class
  • Druggable Genome, Ion Channels: Cys-loop Receptors, Transmembrane
  • Molecular Weight
  • 48.6 kDa
  • TMD
  • 4
  • Sequence
  • MDNGMFSGFIMIKNLLLFCISMNLSSHFGFSQMPTSSVKDETNDNITIFTRILDGLLDGYDNRLRPGLGE
    RITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNGKK
    SIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGST
    KSVVVAEDGSRLNQYHLMGQTVGTENISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFW
    LNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWA
    WDGKKALEAAKIKKKREVILNKSTNAFTTGKMSHPPNIPKEQTPAGTSNTTSVSVKPSEEKTSESKKTYN
    SISKIDKMSRIVFPVLFGTFNLVYWATYLNREPVIKGAASPK

Product Description

  • Expression Systems
  • HEK293T
  • Tag
  • C-Myc/DDK
  • Purification
  • Anti-DDK affinity column followed by conventional chromatography steps
  • Purity
  • > 80% as determined by SDS-PAGE and Coomassie blue staining
  • Buffer
  • 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Target

  • Target Protein
  • GABRA5
  • Full Name
  • Gamma-aminobutyric acid type A receptor subunit alpha5
  • Introduction
  • GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described.
  • Alternative Names
  • EIEE79; GABA(A) receptor subunit alpha-5; gamma-aminobutyric acid (GABA) A receptor, alpha 5

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