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Magic™ Membrane Protein Human GRM1 (Glutamate metabotropic receptor 1) Full Length (CAT#: MPC0184K) Made to Order

Datasheet
This product is a 132.3 kDa Human GRM1 membrane protein expressed in Baculovirus/Insect expression system. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • GRM1
  • Protein Length
  • Full length
  • Protein Class
  • GPCR
  • Molecular Weight
  • 132.3 kDa
  • TMD
  • 7
  • Sequence
  • MVGLLLFFFPAIFLEVSLLPRSPGRKVLLAGASSQRSVARMDGDVIIGAL
    FSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNIT
    LGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCLPDGQSLPPG
    RTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKY
    FLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQ
    EGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLL
    SAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSF
    DDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTGNESL
    EENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGSKL
    LDFLIKSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTW
    HEGVLNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTAC
    KENEYVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFS
    CLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIA
    KPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRF
    MSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTSN
    LGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLA
    FVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAF
    TTSDVVRMHVGDGKLPCRSNTFLNIFRRKKAGAGNANSNGKSVSWSEPGG
    GQVPKGQHMWHRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDTS
    TKTLYNVEEEEDAQPIRFSPPGSPSMVVHRRVPSAATTPPLPSHLTAEET
    PLFLAEPALPKGLPPPLQQQQQPPPQQKSLMDQLQGVVSNFSTAIPDFHA
    VLAGPGGPGNGLRSLYPPPPPPQHLQMLPLQLSTFGEELVSPPADDDDDS
    ERFKLLQEYVYEHEREGNTEEDELEEEEEDLQAASKLTPDDSPALTPPSP
    FRDSVASGSSVPSSPVSESVLCTPPNVSYASVILRDYKQSSSTL

Product Description

  • Expression Systems
  • Baculovirus/Insect expression system
  • Tag
  • Flag tag and 10×His tag at the N-terminus
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • GRM1
  • Full Name
  • Glutamate metabotropic receptor 1
  • Introduction
  • This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
  • Alternative Names
  • MGLU1; SCA44; GPRC1A; MGLUR1; SCAR13; PPP1R85; glutamate receptor, metabotropic 1; protein phosphatase 1, regulatory subunit 85; GRM1; Glutamate metabotropic receptor 1

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