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Magic™ Membrane Protein Human GRM5 (Glutamate metabotropic receptor 5) Expressed in NS0 for Antibody Discovery, Partial (19-509aa) (CAT#: MPX0044K)

Datasheet
This product is a 56 kDa Human GRM5 membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • GRM5
  • Protein Length
  • Partial (19-509aa)
  • Protein Class
  • GPCR
  • Molecular Weight
  • 56 kDa
  • TMD
  • 7
  • Sequence
  • SAQSSERRVVAHMPGDIIIGALFSVHHQPTVD
    KVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCW
    HSAVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSSFRSKKPIVGVIGPG
    SSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQAR
    AMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYS
    NAGEQSFDKLLKKLTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFL
    LLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNH
    RNPWFQEFWQHRFQCRLEGFPQENSKYNKTCNSSLTLKTHHVQDSKMGFV
    INAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLESLMKTNFTGVS
    GDTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMDDDEVW
    SKKSNIIRS

Product Description

  • Expression Systems
  • NS0
  • Tag
  • 6xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 250 μg/mL in PBS.
  • Endotoxin
  • <0.1 EU/μg by the LAL method
  • Purity
  • >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • GRM5
  • Full Name
  • Glutamate metabotropic receptor 5
  • Introduction
  • This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • mGlu5; GPRC1E; MGLUR5; PPP1R86; glutamate receptor, metabotropic 5; protein phosphatase 1, regulatory subunit 86; GRM5; Glutamate metabotropic receptor 5

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