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Magic™ Membrane Protein Human GRM8 (Glutamate metabotropic receptor 8) Expressed in CHO for Antibody Discovery, Partial (34-514aa) (CAT#: MPX0046K)

Datasheet
This product is a 55 kDa Human GRM8 membrane protein expressed in CHO. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • GRM8
  • Protein Length
  • Partial (34-514aa)
  • Protein Class
  • GPCR
  • Molecular Weight
  • 55 kDa
  • TMD
  • 7
  • Sequence
  • QEYAHSI
    RVDGDIILGG
    LFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGV
    RILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGV
    IGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS
    YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQS
    QKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQS
    GHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTL
    ANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEG
    KVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVN
    FNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVE
    DMQWAHREHTHPAS

Product Description

  • Expression Systems
  • CHO
  • Tag
  • 6xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 250 μg/mL in PBS.
  • Endotoxin
  • <0.1 EU/μg by the LAL method
  • Purity
  • >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • GRM8
  • Full Name
  • Glutamate metabotropic receptor 8
  • Introduction
  • L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
  • Alternative Names
  • GLUR8; mGlu8; GPRC1H; MGLUR8; glutamate receptor, metabotropic 8; GRM8; Glutamate metabotropic receptor 8

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