Magic™ Membrane Protein Human HERPUD1 (Homocysteine inducible ER protein with ubiquitin like domain 1) Full Length (CAT#: MPC3653K) Made to Order

Name: Magic™ Membrane Protein Human HERPUD1 (Homocysteine inducible ER protein with ubiquitin like domain 1) Full Length
SKU: MPC3653K
Rating: 5 (1 reviews)

Datasheet

This product is a made-to-order Human HERPUD1 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

Host Species
Human

Target Protein
HERPUD1

Protein Length
Full length

Protein Class
Receptor

Sequence
MESETEPEPVTLLVKSPNQRHRDLELSGDRGWSVGHLKAHLSRVYPERPR
PEDQRLIYSGKLLLDHQCLRDLLPKQEKRHVLHLVCNVKSPSKMPEINAK
VAESTEEPAGSNRGQYPEDSSSDGLRQREVLRNLSSPGWENISRPEAAQQ
AFQGLGPGFSGYTPYGWLQLSWFQQIYARQYYMQYLAATAASGAFVPPPS
AQEIPVVSAPAPAPIHNQFPAENQPANQNAAPQVVVNPGANQNLRMNAQG
GPIVEEDDEINRDWLDWTYSAATFSVFLSILYFYSSLSRFLMVMGATVVM
YLHHVGWFPFRPRPVQNFPNDGPPPDVVNQDPNNNLQEGTDPETEDPNHL
PPDRDVLDGEQTSPSFMSTAWLVFKTFFASLLPEGPPAIAN

Product Description

Expression Systems
HEK293

Tag
Flag-StrepII or based on specific requirements

Protein Format
Detergent or based on specific requirements (Detergent, Liposome, Nanodisc, Polymer, VLP)

Target

Target Protein
HERPUD1

Full Name
Homocysteine inducible ER protein with ubiquitin like domain 1

Introduction
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. The full-length nature of all transcript variants has not been determined.

Alternative Names
HERPUD1; SUP; HERP; Mif1; homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein; MMS-inducible; homocysteine-inducible endoplasmic reticulum stress-inducible ubiquitin-like domain member 1 protein; homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1; methyl methanesulfonate (MMF)-inducible fragment protein 1; Homocysteine inducible ER protein with ubiquitin like domain 1

Gene ID
9709

UniProt ID
Q15011

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