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Magic™ Membrane Protein Human KCNQ4 (Potassium voltage-gated channel subfamily Q member 4) Full Length (CAT#: MPC0639K) Made to Order

Datasheet
This product is a 77.1 kDa Human KCNQ4 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • KCNQ4
  • Protein Length
  • Full length
  • Protein Class
  • Transporter; Ion channel
  • Molecular Weight
  • 77.1 kDa
  • TMD
  • 6
  • Sequence
  • MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGS
    PLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFV
    YHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVR
    VWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFAT
    SALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLI
    FASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLA
    AGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAW
    RLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVR
    RAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTG
    PSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPR
    TSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFK
    ETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKG
    DKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSA
    SLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • KCNQ4
  • Full Name
  • Potassium voltage-gated channel subfamily Q member 4
  • Introduction
  • The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene.
  • Alternative Names
  • DFNA2; KV7.4; DFNA2A; potassium voltage-gated channel subfamily KQT member 4; potassium channel KQT-like 4; potassium channel subunit alpha KvLQT4; potassium channel, voltage gated KQT-like subfamily Q, member 4; potassium voltage-gated channel, KQT-like subfamily, member 4; KCNQ4; Potassium voltage-gated channel subfamily Q member 4

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