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Magic™ Membrane Protein Human KIRREL3 (Kirre like nephrin family adhesion molecule 3) Expressed in NS0 for Antibody Discovery, Partial (29-535aa) (CAT#: MPX0666K)

Datasheet
This product is a 56.1 kDa Human KIRREL3 membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • KIRREL3
  • Protein Length
  • Partial (29-535aa)
  • Protein Class
  • Receptor
  • Molecular Weight
  • 56.1 kDa
  • TMD
  • 1
  • Sequence
  • LVLGYMAKDKFRRMNEGQVYSF
    SQQPQDQVVVSGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYL
    VVGNHLSGEHHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDP
    VILGGPVISLRAGDPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLL
    RDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQHPP
    LVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYR
    TTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGS
    DAIFSCAWTGNPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRA
    VVPRVGAGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTPPPDR
    IAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCT
    AWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMA

Product Description

  • Activity
  • Yes
  • Expression Systems
  • NS0
  • Tag
  • 6xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 100 μg/mL in sterile PBS.
  • Endotoxin
  • <0.10 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >95%, by SDS-PAGE under reducing conditions and visualized by silver stain
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • KIRREL3
  • Full Name
  • Kirre like nephrin family adhesion molecule 3
  • Introduction
  • The protein encoded by this gene is a member of the nephrin-like protein family. These proteins are expressed in fetal and adult brain, and also in podocytes of kidney glomeruli. The cytoplasmic domains of these proteins interact with the C-terminus of podocin, also expressed in the podocytes, cells involved in ensuring size- and charge-selective ultrafiltration. The protein encoded by this gene is a synaptic cell adhesion molecule with multiple extracellular immunoglobulin-like domains and a cytoplasmic PDZ domain-binding motif. Mutations in this gene are associated with several neurological and cognitive disorders. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Alternative Names
  • KIRREL3; MRD4; KIRRE; NEPH2; PRO4502; kin of IRRE-like protein 3; kin of IRRE like 3; kin of irregular chiasm-like protein 3; nephrin-like 2; nephrin-like protein 2; Kirre like nephrin family adhesion molecule 3

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