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Magic™ Membrane Protein Human LARGE1 (LARGE xylosyl- and glucuronyltransferase 1) Full Length (CAT#: MPC2289K) Made to Order

Datasheet
This product is a 88 kDa Human LARGE1 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • LARGE1
  • Protein Length
  • Full length
  • Protein Class
  • Transferase
  • Molecular Weight
  • 88 kDa
  • TMD
  • 1
  • Sequence
  • MLGICRGRRKFLAASLSLLCIPAITWIYLFSGSFEDGKPVSLSPLESQAH
    SPRYTASSQRERESLEVRMREVEEENRALRRQLSLAQGRAPSHRRGNHSK
    TYSMEEGTGDSENLRAGIVAGNSSECGQQPVVEKCETIHVAIVCAGYNAS
    RDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYN
    ADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATD
    IAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVI
    LLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVY
    QLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNL
    YLTFLEYDGNLLRRELFGCPSEADVNSENLQKQLSELDEDDLCYEFRRER
    FTVHRTHLYFLHYEYEPAADSTDVTLVAQLSMDRLQMLEAICKHWEGPIS
    LALYLSDAEAQQFLRYAQGSEVLMSRHNVGYHIVYKEGQFYPVNLLRNVA
    MKHISTPYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETL
    RYRLSFPKSKAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKWRTATTPYR
    VEWEADFEPYVVVRRDCPEYDRRFVGFGWNKVAHIMELDVQEYEFIVLPN
    AYMIHMPHAPSFDITKFRSNKQYRICLKTLKEEFQQDMSRRYGFAALKYL
    TAENNS

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • StrepII and Flag tag at the N-terminus
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • LARGE1
  • Full Name
  • LARGE xylosyl- and glucuronyltransferase 1
  • Introduction
  • This gene encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. The protein encoded by this gene is the glycotransferase that adds the final xylose and glucuronic acid to alpha-dystroglycan and thereby allows alpha-dystroglycan to bind ligands including laminin 211 and neurexin. Mutations in this gene cause several forms of congenital muscular dystrophy characterized by cognitive disability and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in multiple transcript variants that encode the same protein.
  • Alternative Names
  • LARGE1; LARGE; MDC1D; MDDGA6; MDDGB6; acetylglucosaminyltransferase-like 1A; acetylglucosaminyltransferase-like protein; glycosyltransferase-like protein LARGE1; LARGE xylosyl- and glucuronyltransferase 1

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