Close
Close

Magic™ Membrane Protein Human NPHS1 (NPHS1 adhesion molecule, nephrin) Expressed in NS0 for Antibody Discovery, Partial (23-1029aa) (CAT#: MPX0286K)

Datasheet
This product is a 110 kDa Human NPHS1 membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • NPHS1
  • Protein Length
  • Partial (23-1029aa)
  • Protein Class
  • Cell adhesion
  • Molecular Weight
  • 110 kDa
  • TMD
  • 1
  • Sequence
  • QLAIPASVPRGFWALPENLTVVEGASVE
    LRCGVSTPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHLHIEA
    CDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTW
    VAGQEYVVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEA
    TARVTPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGL
    DEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARS
    VLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGSAS
    QTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGGHISMS
    NLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPP
    EGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLG
    SVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQLSASTQLAVQFPPTNVTI
    LANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFK
    GSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLG
    EQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILS
    SGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPTE
    VNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGR
    LRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVA
    AAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVH
    SSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPDPPSGLKVV
    SLTPHSVGLEWKPGFDGGLPQRFCIRYEALGTPGFHYVDVVPPQATTFTL
    TGLQPSTRYRVWLLASNALGDSGLADKGT

Product Description

  • Expression Systems
  • NS0
  • Tag
  • 6xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 500 μg/mL in PBS.
  • Endotoxin
  • <0.10 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.

Target

  • Target Protein
  • NPHS1
  • Full Name
  • NPHS1 adhesion molecule, nephrin
  • Introduction
  • This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.
  • Alternative Names
  • NPHS1; CNF; NPHN; nephrin; nephrin; NPHS1, nephrin; nephrosis 1, congenital, Finnish type (nephrin); renal glomerulus-specific cell adhesion receptor; truncated NPHS1; NPHS1 adhesion molecule, nephrin

Customer reviews and Q&As    

Related Products
Online Inquiry
CONTACT US
USA:
Europe:
Germany:
Call us at:
USA:
UK:
Germany:
Fax:
Email:
Our customer service representatives are available 24 hours a day, 7 days a week. Contact Us
© 2024 Creative Biolabs. | Contact Us