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Magic™ Membrane Protein Human NTRK1 (Neurotrophic receptor tyrosine kinase 1) Expressed in HEK293 for Antibody Discovery, Partial (34-423aa) (CAT#: MPX0128K)

Datasheet
This product is a 43 kDa Human NTRK1 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • NTRK1
  • Protein Length
  • Partial (34-423aa)
  • Protein Class
  • Receptor
  • Molecular Weight
  • 43 kDa
  • TMD
  • 1
  • Sequence
  • APCPDACCPHGSSGLRC
    TRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVK
    SGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPL
    HCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQV
    PNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLT
    LANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWC
    IPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQ
    PTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDT
    NSTSGDPVEKKDETPFGVSVAVG

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • 6xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 1 mg/mL in PBS.
  • Endotoxin
  • <1.0 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • NTRK1
  • Full Name
  • Neurotrophic receptor tyrosine kinase 1
  • Introduction
  • This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
  • Alternative Names
  • NTRK1; MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA; high affinity nerve growth factor receptor; Oncogene TRK; TRK1-transforming tyrosine kinase protein; gp140trk; neurotrophic tyrosine kinase, receptor, type 1; tropomyosin-related kinase A; tyrosine kinase receptor A; Neurotrophic receptor tyrosine kinase 1

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