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Magic™ Membrane Protein Human PCDHA12 (Protocadherin alpha 12) Full Length (CAT#: MPC4367K) Made to Order

Datasheet
This product is a made-to-order Human PCDHA12 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • PCDHA12
  • Protein Length
  • Full length
  • Protein Class
  • Cell adhesion
  • TMD
  • 1
  • Sequence
  • MVIIGPRGPGSQRLLLSLLLLAAWEVGSGQLHYSVYEEAKHGTFVGRIAQ
    DLGLELAELVPRLFRVASKRHGDLLEVNLQNGILFVNSRIDREKLCGRSA
    ECSIHLEVIVDRPLQVFHVDVEVKDINDNPPVFREREQKVPVSESAPLDS
    HFPLEGASDADIGVNSLLTYALSLNENFELKIKTKKDKSILPELVLRKLL
    DREQTPKLNLLLMVIDGGKPELTGSVQIQITVLDVNDNGPAFDKPSYKVV
    LSENVQNDTRVIQLNASDPDEGLNGEISYGIKMILPVSEKCMFSINPDTG
    EIRIYGELDFEENNAYEIQVNAIDKGIPSMAGHSMVLVEVLDVNDNVPEV
    MVTSLSLPVQEDAQVGTVIALISVSDRDSGANGQVICSLTPHVPFKLVST
    YKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVND
    NAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQKNALVSYSLVERRVG
    EHALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVT
    LQVFVLDENDNAPALLATPAGSAGGAVSELVPRSVGAGHVVAKVRAVDAD
    SGYNAWLSYELQPAAVGAHIPFHVGLYTGEISTTRILDEADAPRHRLLVL
    VKDHGEPALTSTATVLVSLVENGQAPKTSSRASVGAVDPEAALVDINVYL
    IIAICAVSSLLVLTLLLYTALRCSAPPTVSRCAPGKPTLVCSSAVGSWSY
    SQQRRQRVCSAESPPKTDLMAFSPSLQLSREDCLNPPSEPRQPNPDWRYS
    ASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVG
    AGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQID
    KSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements (Detergent, Liposome, Nanodisc, SMALPs, VLP)

Target

  • Target Protein
  • PCDHA12
  • Full Name
  • Protocadherin alpha 12
  • Introduction
  • This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
  • Alternative Names
  • PCDHA12; PCDH-ALPHA12; protocadherin alpha-12; KIAA0345-like 2; PCDH-alpha-12; Protocadherin alpha 12

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