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Magic™ Membrane Protein Human PCDHGA12 (Protocadherin gamma subfamily A, 12) Full Length (CAT#: MPC2744K) Made to Order

Datasheet
This product is a made-to-order Human PCDHGA12 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • PCDHGA12
  • Protein Length
  • Full length
  • Protein Class
  • Cell adhesion
  • TMD
  • 1
  • Sequence
  • MIPARLHRDYKGLVLLGILLGTLWETGCTQIRYSVPEELEKGSRVGDISR
    DLGLEPRELAERGVRIIPRGRTQLFALNPRSGSLVTAGRIDREELCMGAI
    KCQLNLDILMEDKVKIYGVEVEVRDINDNAPYFRESELEIKISENAATEM
    RFPLPHAWDPDIGKNSLQSYELSPNTHFSLIVQNGADGSKYPELVLKRAL
    DREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPEYRAS
    VPENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDDKAAQVFKLDCNSGT
    ISTIGELDHEESGFYQMEVQAMDNAGYSARAKVLITVLDVNDNAPEVVLT
    SLASSVPENSPRGTLIALLNVNDQDSEENGQVICFIQGNLPFKLEKSYGN
    YYSLVTDIVLDREQVPSYNITVTATDRGTPPLSTETHISLNVADTNDNPP
    VFPQASYSAYIPENNPRGVSLVSVTAHDPDCEENAQITYSLAENTIQGAS
    LSSYVSINSDTGVLYALSSFDYEQFRDLQVKVMARDNGHPPLSSNVSLSL
    FVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQ
    NAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHG
    QPPLSATVTLTVAVADSIPQVLADLGSLESPANSETSDLTLYLVVAVAAV
    SCVFLAFVILLLALRLRRWHKSRLLQASGGGLTGAPASHFVGVDGVQAFL
    QTYSHEVSLTTDSRKSHLIFPQPNYADMLVSQESFEKSEPLLLSGDSVFS
    KDSHGLIEQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQA
    MILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGS
    NATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements (Detergent, Liposome, Nanodisc, SMALPs, VLP)

Target

  • Target Protein
  • PCDHGA12
  • Full Name
  • Protocadherin gamma subfamily A, 12
  • Introduction
  • This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
  • Alternative Names
  • PCDHGA12; FIB3; CDH21; PCDH-GAMMA-A12; protocadherin gamma-A12; cadherin 21; fibroblast cadherin FIB3; fibroblast cadherin-3; Protocadherin gamma subfamily A, 12

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