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Magic™ Membrane Protein Human PORCN (Porcupine O-acyltransferase) (CAT#: MP0030F)

Datasheet
PORCN is an endoplasmic reticulum (ER) enzyme, belonging to the « membrane bounded O-acyltransferase » family. It allows the palmitoylation of proteins involved in the Wnt (Wingless and int homologue) pathway. In the ER, the active site of PORCN presents a histidine residue which has to be protonated for the protein activity.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • PORCN
  • Protein Length
  • Full Length
  • Protein Class
  • Enzyme
  • Molecular Weight
  • 51 kDa
  • TMD
  • 8
  • Sequence
  • MATFSRQEFFQQLLQGCLLPTAQQGLDQIWLLLAICLACRLLWRLGLPSYLKHASTVAGG
    FFSLYHFFQLHMVWVVLLSLLCYLVLFLCRHSSHRGVFLSVTILIYLLMGEMHMVDTVTW
    HKMRGAQMIVAMKAVSLGFDLDRGEVGTVPSPVEFMGYLYFVGTIVFGPWISFHSYLQAV
    QGRPLSCRWLQKVARSLALALLCLVLSTCVGPYLFPYFIPLNGDRLLRNKKRKARGTMVR
    WLRAYESAVSFHFSNYFVGFLSEATATLAGAGFTEEKDHLEWDLTVSKPLNVELPRSMVE
    VVTSWNLPMSYWLNNYVFKNALRLGTFSAVLVTYAASALLHGFSFHLAAVLLSLAFITYV
    EHVLRKRLARILSACVLSKRCPPDCSHQHRLGLGVRALNLLFGALAIFHLAYLGSLFDVD
    VDDTTEEQGYGMAYTVHKWSELSWASHWVTFGCWIFYRLIG

Product Description

  • Activity
  • To be tested
  • Application
  • Screening & display technologies, Antibody development, Structural Biology
  • Expression Systems
  • Cell-free expression system in the presence of lipid vesicles
  • Tag
  • Histidine tag fused to the N-terminal end of the protein
  • Protein Format
  • Proteoliposome
  • Purification
  • Sucrose gradient
  • Purity
  • >50% by SDS-Page and Coomassie Blue staining
  • Buffer
  • Tris 50mM, pH 7.5

Target

  • Target Protein
  • PORCN
  • Full Name
  • Porcupine O-acyltransferase
  • Introduction
  • This gene belongs to the evolutionarily conserved porcupine (Porc) gene family. Genes of the porcupine family encode endoplasmic reticulum proteins with multiple transmembrane domains. Porcupine proteins are involved in the processing of Wnt (wingless and int homologue) proteins. Disruption of this gene is associated with focal dermal hypoplasia, and the encoded protein has been implicated in cancer. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.
  • Alternative Names
  • PPN, DHOF, FODH, MG61, PORC

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