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Magic™ Membrane Protein Human PTAFR (Platelet activating factor receptor) Full Length (CAT#: MPC0342K) Made to Order

Datasheet
This product is a 39.2 kDa Human PTAFR membrane protein expressed in Baculovirus/Insect expression system. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • PTAFR
  • Protein Length
  • Full length
  • Protein Class
  • GPCR
  • Molecular Weight
  • 39.2 kDa
  • TMD
  • 7
  • Sequence
  • MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFN
    EIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFIN
    TYCSVAFLGVITYNRFQAVTRPIKTAQANTRKRGISLSLVIWVAIVGAAS
    YFLILDSTNTVPDSAGSGNVTRCFEHYEKGSVPVLIIHIFIVFSFFLVFL
    IILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAVFIICFVPHHV
    VQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKF
    RKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN

Product Description

  • Expression Systems
  • Baculovirus/Insect expression system
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • PTAFR
  • Full Name
  • Platelet activating factor receptor
  • Introduction
  • This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • PAFR; platelet-activating factor receptor; PAF-R; PTAFR; Platelet activating factor receptor

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