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Magic™ Membrane Protein Human PTPRN2 (Protein tyrosine phosphatase receptor type N2) Full Length (CAT#: MPC2049K) Made to Order

Datasheet
This product is a 111.2 kDa Human PTPRN2 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • PTPRN2
  • Protein Length
  • Full length
  • Protein Class
  • Receptor
  • Molecular Weight
  • 111.2 kDa
  • TMD
  • 1
  • Sequence
  • MGPPLPLLLLLLLLLPPRVLPAAPSSVPRGRQLPGRLGCLLEEGLCGASE
    ACVNDGVFGRCQKVPAMDFYRYEVSPVALQRLRVALQKLSGTGFTWQDDY
    TQYVMDQELADLPKTYLRRPEASSPARPSKHSVGSERRYSREGGAALANA
    LRRHLPFLEALSQAPASDVLARTHTAQDRPPAEGDDRFSESILTYVAHTS
    ALTYPPGSRTQLREDLLPRTLGQLQPDELSPKVDSGVDRHHLMAALSAYA
    AQRPPAPPGEGSLEPQYLLRAPSRMPRPLLAPAAPQKWPSPLGDSEDPSS
    TGDGARIHTLLKDLQRQPAEVRGLSGLELDGMAELMAGLMQGVDHGVARG
    SPGRAALGESGEQADGPKATLRGDSFPDDGVQDDDDRLYQEVHRLSATLG
    GLLQDHGSRLLPGALPFARPLDMERKKSEHPESSLSSEEETAGVENVKSQ
    TYSKDLLGQQPHSEPGAAAFGELQNQMPGPSKEEQSLPAGAQEALSDGLQ
    LEVQPSEEEARGYIVTDRDPLRPEEGRRLVEDVARLLQVPSSAFADVEVL
    GPAVTFKVSANVQNVTTEDVEKATVDNKDKLEETSGLKILQTGVGSKSKL
    KFLPPQAEQEDSTKFIALTLVSLACILGVLLASGLIYCLRHSSQHRLKEK
    LSGLGGDPGADATAAYQELCRQRMATRPPDRPEGPHTSRISSVSSQFSDG
    PIPSPSARSSASSWSEEPVQSNMDISTGHMILSYMEDHLKNKNRLEKEWE
    ALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDY
    INASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAE
    NGVRQCYHYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNET
    RTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAG
    RSGTYVLIDMVLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALT
    AVAEEVNAILKALPQ

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • PTPRN2
  • Full Name
  • Protein tyrosine phosphatase receptor type N2
  • Introduction
  • This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • PTPRN2; IAR; ICAAR; PTPRP; IA-2beta; R-PTP-N2; receptor-type tyrosine-protein phosphatase N2; IAR/receptor-like protein-tyrosine phosphatase; islet cell autoantigen-related protein; phogrin; protein tyrosine phosphatase receptor pi; protein tyrosine phosphatase, receptor type, N polypeptide 2; tyrosine phosphatase IA-2 beta; Protein tyrosine phosphatase receptor type N2

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