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Magic™ Membrane Protein Human RNF217 (Ring finger protein 217) Full Length (CAT#: MPC2587K) Made to Order

Datasheet
This product is a made-to-order Human RNF217 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • RNF217
  • Protein Length
  • Full length
  • Protein Class
  • Transferase
  • TMD
  • 1
  • Sequence
  • MGEEQSTVSGGGGPQESQTLASGTAGHPEPPRPQGDSARAPPLRAASAEP
    SGGGCGSDWGCADTSAPEPARSLGPPGWSKSRAPAQPAGLALTGPLNPQT
    LPLQLELEEEEEEAGDRKEGGDEQQEAPPGEELEPRTRVGAADGLVLDVL
    GQRRPSLAKRQVFCSVYCVESDLPEAPASEQLSPPASPPGAPPVLNPPST
    RSSFPSPRLSLPTDSLSPDGGSIELEFYLAPEPFSMPSLLGAPPYSGLGG
    VGDPYVPLMVLMCRVCLEDKPIKPLPCCKKAVCEECLKVYLSAQVQLGQV
    EIKCPITECFEFLEETTVVYNLTHEDSIKYKYFLELGRIDSSTKPCPQCK
    HFTTFKKKGHIPTPSRSESKYKIQCPTCQFVWCFKCHSPWHEGVNCKEYK
    KGDKLLRHWASEIEHGQRNAQKCPKCKIHIQRTEGCDHMTCSQCNTNFCY
    RCGERYRQLRFFGDHTSNLSIFGCKYRYLPERPHLRRLVRGSVCAGKLFI
    APLIMVLGLALGAIAVVIGLFVFPIYCLCKKQRKRSRTGMHW

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements (Detergent, Liposome, Nanodisc, SMALPs, VLP)

Target

  • Target Protein
  • RNF217
  • Full Name
  • Ring finger protein 217
  • Introduction
  • This protein encoded by this gene is a member of the RING1-IBR-RING24 (RBR) ubiquitin protein ligase family, and it belongs to a subfamily of these proteins that contain a transmembrane domain. This protein can interact with the HAX1 anti-apoptotic protein via its C-terminal RING finger motif, which suggests a role in apoptosis signaling. It is thought that deregulation of this gene can be a mechanism in leukemogenesis. Mutations in the region encoding the protein GXXXG motif, which appears to be necessary for protein self-association, have been found in human cancers. Alternative splicing of this gene results in multiple transcript variants.
  • Alternative Names
  • RNF217; OSTL; IBRDC1; C6orf172; dJ84N20.1; probable E3 ubiquitin-protein ligase RNF217; IBR domain containing 1; opposite STL; Ring finger protein 217

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