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Magic™ Membrane Protein Human RXFP1 (Relaxin family peptide receptor 1) (CAT#: MP0031F)

Datasheet
The relaxin/insulin-like family peptide receptor 1 is the cognate receptor for human relaxin-2 in humans. Human RXFP1 also known as LGR7 is located on chromosome 4q32.1 and is known to activate Erk1/2, tyrosine kinase(s), gene transcription, and nitric oxide (NO) signaling and can also interact with the glucocorticoid receptor (GC).
hRXFP1 is found in a wide range of reproductive tissues including ovary, uterus, placenta, mammary gland, prostate, and testis. The receptor is also present in the heart, kidney, lung, liver and blood cells as well as in a number of areas of the brain such as cortex, organum vasculosum of the lamina terminalis (OVLT), and subfornical organ (SFO). RXFP1 binds peptide hormones consequently relaxin not only has autocrine and paracrine roles but also acts as a neuropeptide. It's a potent chronotropic with inotropic effects on the human heart. Relaxin peptide (RLN) has shown therapeutic effects in an acute heart failure clinical trial.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • RXFP1
  • Protein Length
  • Full Length
  • Protein Class
  • GPCR Class A
  • Molecular Weight
  • 86.9 kDa
  • TMD
  • 7
  • Sequence
  • MTSGSVFFYILIFGKYFSHGGGQDVKCSLGYFPCGNITKCLPQLLHCNGVDDCGNQADED
    NCGDNNGWSLQFDKYFASYYKMTSQYPFEAETPECLVGSVPVQCLCQGLELDCDETNLRA
    VPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLY
    LSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDK
    PLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDEL
    DLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQ
    RMFRPLMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAVTC
    FGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWM
    ESTHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGF
    IVAFIPLSNKEFFKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYG
    SMFYSVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGT
    ITSWVVIFILPINSALNPILYTLTTRPFKEMIHRFWYNYRQRKSMDSKGQKTYAPSFIWV
    EMWPLQEMPPELMKPDLFTYPCEMSLISQSTRLNSYS

Product Description

  • Activity
  • Validated by SPRi
  • Application
  • Screening & display technologies, Structural biology, Antibody development
  • Expression Systems
  • Cell-free expression system in the presence of lipid vesicles
  • Tag
  • Histidine tag fused to the N-terminal end of the protein
  • Protein Format
  • Proteoliposome
  • Purification
  • Sucrose gradient
  • Purity
  • >70% by SDS-Page and Coomassie Blue staining
  • Buffer
  • Tris 50mM, pH 7.5

Target

  • Target Protein
  • RXFP1
  • Full Name
  • Relaxin family peptide receptor 1
  • Introduction
  • This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
  • Alternative Names
  • LGR7, RXFPR1

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