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Magic™ Membrane Protein Human SCN11A (Sodium voltage-gated channel alpha subunit 11) Full Length (CAT#: MPC0698K) Made to Order

Datasheet
This product is a 204.9 kDa Human SCN11A membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • SCN11A
  • Protein Length
  • Full length
  • Protein Class
  • Transporter; Ion channel
  • Molecular Weight
  • 204.9 kDa
  • TMD
  • 24
  • Sequence
  • MDDRCYPVIFPDERNFRPFTSDSLAAIEKRIAIQKEKKKSKDQTGEVPQP
    RPQLDLKASRKLPKLYGDIPRELIGKPLEDLDPFYRNHKTFMVLNRKRTI
    YRFSAKHALFIFGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGP
    AKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDS
    IVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSV
    KKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHC
    FEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFL
    AMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVT
    MAYEEQNKNVAAEIEAKEKMFQEAQQLLKEEKEALVAMGIDRSSLTSLET
    SYFTPKKRKLFGNKKRKSFFLRESGKDQPPGSDSDEDCQKKPQLLEQTKR
    LSQNLSLDHFDEHGDPLQRQRALSAVSILTITMKEQEKSQEPCLPCGENL
    ASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHK
    MEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVAL
    LSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGA
    LGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWH
    MGDFWHSFLVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIGKL
    VVLNLFIALLLNSFSNEERNGNLEGEARKTKVQLALDRFRRAFCFVRHTL
    EHFCHKWCRKQNLPQQKEVAGGCAAQSKDIIPLVMEMKRGSETQEELGIL
    TSVPKTLGVRHDWTWLAPLAEEEDDVEFSGEDNAQRITQPEPEQQAYELH
    QENKKPTSQRVQSVEIDMFSEDEPHLTIQDPRKKSDVTSILSECSTIDLQ
    DGFGWLPEMVPKKQPERCLPKGFGCCFPCCSVDKRKPPWVIWWNLRKTCY
    QIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHI
    FILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLINLMELKSFRTLR
    ALRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFF
    SGKFGKCINGTDSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLAL
    LQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTL
    NLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPR
    PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDH
    LNWVFVVIFTLECLIKIFALRQYYFTNGWNLFDCVVVLLSIVSTMISTLE
    NQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNI
    GLLLFLIMFIYAILGMNWFSKVNPESGIDDIFNFKTFASSMLCLFQISTS
    AGWDSLLSPMLRSKESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYI
    AVILENFNTATEESEDPLGEDDFDIFYEVWEKFDPEATQFIKYSALSDFA
    DALPEPLRVAKPNKYQFLVMDLPMVSEDRLHCMDILFAFTARVLGGSDGL
    DSMKAMMEEKFMEANPLKKLYEPIVTTTKRKEEERGAAIIQKAFRKYMMK
    VTKGDQGDQNDLENGPHSPLQTLCNGDLSSFGVAKGKVHCD

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • SCN11A
  • Full Name
  • Sodium voltage-gated channel alpha subunit 11
  • Introduction
  • Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is highly expressed in nociceptive neurons of dorsal root ganglia and trigeminal ganglia. It mediates brain-derived neurotrophic factor-evoked membrane depolarization and is a major effector of peripheral inflammatory pain hypersensitivity. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy type VII and familial episodic pain syndrome-3. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • NaN; PN5; FEPS3; HSAN7; SNS-2; NAV1.9; SCN12A; sodium channel protein type 11 subunit alpha; peripheral nerve sodium channel 5; sensory neuron sodium channel 2; sodium channel protein type XI subunit alpha; sodium channel, voltage-gated, type XI, alpha polypeptide; sodium channel, voltage-gated, type XI, alpha subunit; sodium channel, voltage-gated, type XII, alpha polypeptide; voltage-gated sodium channel subunit alpha Nav1.9; SCN11A; Sodium voltage-gated channel alpha subunit 11

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