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Magic™ Membrane Protein Human SLC12A6 (Solute carrier family 12 member 6) Full Length (CAT#: MPC0727K) Made to Order

This product is a 127.6 kDa Human SLC12A6 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • SLC12A6
  • Protein Length
  • Full length
  • Protein Class
  • Transporter; Ion channel
  • Molecular Weight
  • 127.6 kDa
  • TMD
  • 12
  • Sequence
  • MHPPETTTKMASVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSRES
    VPETSRSEPMSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITGE
    HSQLLDDGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLL
    NRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIF
    GVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAG
    GSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAA
    IFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLAC
    VIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMT
    VPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSN
    YLPKGEIIEKPSAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIM
    AGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDK
    FGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAK
    DNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFF
    LMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSW
    YYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPP
    HTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNF
    LENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGG
    MKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFP
    SNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLE
    DNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQM
    LRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWT
    KDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHE
    AKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag tag at the N-terminus and StrepII tag at the C-terminus
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • SLC12A6
  • Full Name
  • Solute carrier family 12 member 6
  • Introduction
  • This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy.
  • Alternative Names
  • KCC3; ACCPN; KCC3A; KCC3B; solute carrier family 12 member 6; K-Cl cotransporter 3; electroneutral potassium-chloride cotransporter 3; potassium chloride cotransporter 3; potassium chloride cotransporter KCC3a-S3; potassium-chloride transporter-3a; potassium-chloride transporter-3b; solute carrier family 12 (potassium/chloride transporter), member 6; solute carrier family 12 (potassium/chloride transporters), member 6; SLC12A6; Solute carrier family 12 member 6

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