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Magic™ Membrane Protein Human SLC6A4 (Solute carrier family 6 member 4) Full Length (CAT#: MPC0895K) Made to Order

Datasheet
This product is a 70.3 kDa Human SLC6A4 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • SLC6A4
  • Protein Length
  • Full length
  • Protein Class
  • Transporter
  • Molecular Weight
  • 70.3 kDa
  • TMD
  • 12
  • Sequence
  • METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAV
    PSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLG
    NVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISI
    WRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSC
    KNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGG
    ISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA
    TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASY
    NKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKD
    AGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAV
    LDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPA
    VLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLL
    FIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT
    PGTFKERIIKSITPETPTEIPCGDIRLNAV

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • StrepII and 10xHis tag at the C-terminus
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • SLC6A4
  • Full Name
  • Solute carrier family 6 member 4
  • Introduction
  • This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake. There have been conflicting results in the literature about the possible effect, if any, that this polymorphism may play in behavior and depression.
  • Alternative Names
  • HTT; 5HTT; OCD1; SERT; 5-HTT; SERT1; hSERT; 5-HTTLPR; sodium-dependent serotonin transporter; 5-hydroxytryptamine (serotonin) transporter; 5HT transporter; Na+/Cl- dependent serotonin transporter; serotonin transporter 1; solute carrier family 6 (neurotransmitter transporter), member 4; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; SLC6A4; Solute carrier family 6 member 4

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