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Magic™ Membrane Protein Human UGT1A8 (UDP glucuronosyltransferase family 1 member A8) Full Length (CAT#: MPC4428K) Made to Order

Datasheet
This product is a made-to-order Human UGT1A8 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • UGT1A8
  • Protein Length
  • Full length
  • Protein Class
  • Transferase
  • TMD
  • 1
  • Sequence
  • MARTGWTSPIPLCVSLLLTCGFAEAGKLLVVPMDGSHWFTMQSVVEKLIL
    RGHEVVVVMPEVSWQLGKSLNCTVKTYSTSYTLEDLDREFMDFADAQWKA
    QVRSLFSLFLSSSNGFFNLFFSHCRSLFNDRKLVEYLKESSFDAVFLDPF
    DACGLIVAKYFSLPSVVFARGIACHYLEEGAQCPAPLSYVPRILLGFSDA
    MTFKERVRNHIMHLEEHLFCQYFSKNALEIASEILQTPVTAYDLYSHTSI
    WLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIV
    VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVK
    WLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKR
    METKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVE
    PLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVA
    FITFKCCAYGYRKCLGKKGRVKKAHKSKTH

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements (Detergent, Liposome, Nanodisc, SMALPs, VLP)

Target

  • Target Protein
  • UGT1A8
  • Full Name
  • UDP glucuronosyltransferase family 1 member A8
  • Introduction
  • This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including coumarins, phenols, anthraquinones, flavones, and some opioids.
  • Alternative Names
  • UGT1A8; GNT1; UGT1; UDPGT; UGT1A; UGT1H; UGT-1A; UGT-1H; UGT1.1; UGT1.8; UGT1A1; UGT1-01; UGT1-08; UGT1A8S; hUG-BR1; UDPGT 1-1; UDPGT 1-8; UDP-glucuronosyltransferase 1A8; Bilirubin-specific UDPGT isozyme 1; UDP glucuronosyltransferase 1 family, polypeptide A8; UDP glycosyltransferase 1 family, polypeptide A8; UDP-glucuronosyltransferase 1 family polypeptide A8s; UDP-glucuronosyltransferase 1-1; UDP-glucuronosyltransferase 1-8; UDP-glucuronosyltransferase 1-A; UDP-glucuronosyltransferase 1-H; UDP-glucuronosyltransferase 1A1; UDP glucuronosyltransferase family 1 member A8

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