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Magic™ Membrane Protein Mouse Kcna3 (Potassium voltage-gated channel, shaker-related subfamily, member 3) (CAT#: MP0022F)

Datasheet
Kv1.3 is a voltage-gated potassium channel that participates in cellular processes such as neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, apoptosis, cell volume regulation, and T cell stimulation. Kv1.3 channels have been proposed to be crucial in the pathogenesis of multiple sclerosis and other autoimmune diseases Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Product Specifications

  • Host Species
  • Mouse
  • Target Protein
  • Kcna3
  • Protein Length
  • Full Length
  • Protein Class
  • Channel
  • Molecular Weight
  • 58 kDa
  • TMD
  • 6
  • Sequence
  • MTVVPGDHLLEPEAAGGGGGDPPQGGCGSGGGGGGCDRYEPLPPALPAAGEQDCCGERVV
    INISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGG
    RIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYP
    ESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASPSQDVFEAANNSTSGAPSG
    ASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTEL
    AERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFI
    GVILFSSAVYFAEADDPSSGFNSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIA
    GVLTIALPVPVIVSNFNYFYHRETEGEEQAQYMHVGSCQHLSSSAEELRKARSNSTLSKS
    EYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV

Product Description

  • Activity
  • Validated by Patch clamp
  • Application
  • Screening & display technologies, Antibody development, Structural biology
  • Expression Systems
  • Cell-free expression system in the presence of lipid vesicles
  • Tag
  • Histidine tag fused to the N-terminal end of the protein
  • Protein Format
  • Proteoliposome
  • Purification
  • Sucrose gradient
  • Purity
  • >60% by SDS-Page and Coomassie Blue staining
  • Buffer
  • Tris 50mM, pH 7.5

Target

  • Target Protein
  • Kcna3
  • Full Name
  • Potassium voltage-gated channel, shaker-related subfamily, member 3
  • Introduction
  • Kcna3 mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
  • Alternative Names
  • Mk-3, Kv1.3, Kca1-3

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