Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsMajor facilitator superfamily domain-containing protein (MFSD) is a superfamily of membrane transport proteins which is universally known as a second transporter found in a variety of organisms. The transport proteins possess 12 transmembrane helices with a central substrate-binding pocket that determine the specificity of substrates transported. They can transport small solutes across the cell membrane using the already-existing electrochemical gradient, without directly using ATP hydrolytic energy. MFSD is identified as sugar transporters initially. However, following studies reveal that MFSD can act as transporters of a great diversity of substrates, such as small oxyanions, nutrients, drugs, neurotransmitters, and metabolites. MFSD plays a very important role in many biological processes. For example, the MFSD members expressed in the brain contribute to moving nutrients across the blood-brain barrier and clearing neurotransmitters from the synaptic cleft blocking neuronal transmission. Moreover, they function as drug transporters to move the drugs to the specific pathological parts.
There are about 430 MFSD proteins that are divided into solute carriers (SLCs) families and atypical MFS transport families (AMTFs). Here shows part of AMTFs in humans including sodium-dependent lysophosphatidylcholine symporter 1, sphingosine-1-phosphate transporter, sodium-dependent glucose transporter 1, molybdate-anion transporter, ceroid-lipofuscinosis neuronal protein 7. These AMTFs members are associated with the transportation of specific substrates. For example, MFSD4B functions as transport of glucose, bile salts and organic acids, metal ions and amine compounds. While MFSD2B specifically mediates export of sphingosine-1-phosphate in red blood cells and platelets. However, the substrate transported by MFSD8 is not clear.
Aided by cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
