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NativeExtract™ Human CELSR1 Membrane Protein (Full length, Super Nanodisc) (CAT#: S01YF-1023-KX292)

Datasheet
This product is recombinant Human CELSR1 protein in native nanodisc form. The synthetic compound we developed can solubilize the CELSR1 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CELSR1
  • Protein Length
  • Full length
  • Molecular Weight
  • 329.5kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • Flag tag at the C-terminus
  • Protein Format
  • Native Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • CELSR1
  • Full Name
  • Cadherin EGF LAG seven-pass G-type receptor 1
  • Introduction
  • The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis.
  • Alternative Names
  • ME2; FMI2; CDHF9; HFMI2; ADGRC1; cadherin EGF LAG seven-pass G-type receptor 1; adhesion G protein-coupled receptor C1; cadherin family member 9; cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila); flamingo homolog 2; protocadherin flamingo 2; CELSR1; Cadherin EGF LAG seven-pass G-type receptor 1

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