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NativeExtract™ Human CXCR3 Membrane Protein (Full length, Super Nanodisc) (CAT#: S01YF-1023-KX431)

Datasheet
This product is recombinant Human CXCR3 protein in native nanodisc form. The synthetic compound we developed can solubilize the CXCR3 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CXCR3
  • Protein Length
  • Full length
  • Molecular Weight
  • 40.5 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • Flag tag at the C-terminus
  • Protein Format
  • Native Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • CXCR3
  • Full Name
  • C-X-C motif chemokine receptor 3
  • Introduction
  • This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4.
  • Alternative Names
  • GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R; C-X-C chemokine receptor type 3; G protein-coupled receptor 9; IP-10 receptor; Mig receptor; chemokine (C-X-C motif) receptor 3; chemokine receptor 3; interferon-inducible protein 10 receptor; CXCR3; C-X-C motif chemokine receptor 3

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