Services

As an important part of the immune system, natural autoantibodies (NAA) have become hotspots in the immunology field. With experienced scientists and high-end technologies, Creative Biolabs has successfully developed a series of innovative and diversified NAA platforms to provide fast and convenient NAA services for our worldwide customers. Now, we are glad to provide the largest and most diverse portfolio of premade or custom NAA products and services to help you get milestone development.

Overview Significance Service Types Advantages Resource

Overview

Introduction of NAA

Natural autoantibodies (NAA) are a kind of antibodies which have a moderate affinity for self-antigens, including insulin, DNA, thyroglobulin, nucleoproteins and phospholipids, and these biomolecules are also targeted during the progression of autoimmune disorders. NAA arise independently of antigenic or mitogenic stimulation and can be detected in the sera of healthy or sick individuals. NAA are particularly IgM isotype, with a less extent of IgG and IgA isotypes. Low-serum titer, low-affinity to antigens, polyreactivity and connectivity are the main characteristics of NAA.

NAA characteristics overview. (Holodick, Rodríguez-Zhurbenko & Hernández, 2017)Fig. 1 NAA characteristics overview.1

Significance

Clinical Significance of NAA Service

In the early stage of some diseases, NAA are biologically amplified and hence may be measurable early on, making them promising biomarkers to discriminate the pathological changes from healthy tissue accurately. NAA detection and profiling present an alternative to various diseases with advantages of minimalist hardware, short time-frames, and an abundance of targets. Now, screening and early diagnosis with respect to risk stratification are critical for prevention and early intervention of numerous diseases, leading to better therapeutic outcomes. So, efficient, low-cost, and highly sensitive NAA services are useful and essential in early detection, disease stratification, and monitoring of treatment responses of multiple diseases.

Natural IgM in immune equilibrium.Fig. 2 Natural IgM in immune equilibrium.2

Service Types

What Can We Do About NAA?

With years of experience and advanced technologies, Creative Biolabs can provide one-stop NAA services, from NAA detection, NAA profiling, to NAA epitope mapping. In addition, a wide spectrum of NAA products is available for your choice.

Advantages

Why Choose Us?

Flowchart of autoantibody biomarker discovery and detection in breast cancer.Fig. 3 Flowchart of autoantibody biomarker discovery and detection in breast cancer.3


Creative Biolabs is capable to provide comprehensive products and services about NAA. Our proven and optimized platforms can help you quickly get satisfactory results without repeated trials. We also provide custom services based on the requirements of the clients to meet the specific demand. If you are interested, please contact us for more information.

Quotations and ordering. (Creative Biolabs Original)

Our customer service agents are accessible 24/7, from Monday to Friday, to aid you.

Resource

NAA Detection Kits Flyer

References

  1. Holodick, Nichol E., Nely Rodríguez-Zhurbenko, and Ana María Hernández. "Defining natural antibodies." Frontiers in immunology 8 (2017): 872.
  2. Kaveri, Srini V., Gregg J. Silverman, and Jagadeesh Bayry. "Natural IgM in immune equilibrium and harnessing their therapeutic potential." The Journal of Immunology 188.3 (2012): 939-945.
  3. Qiu, Jingyi, et al. "Autoantibodies as potential biomarkers in breast cancer." Biosensors 8.3 (2018): 67.
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