Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsOver the past decade, we have made exciting progress in the understanding of the physiology, pathology, and pharmacology of members of the solute carrier family 1 (SLC1), including high-affinity glutamate and neutral amino acid transporters. Glutamate transporters play a critical role in terminating excitatory neurotransmission and providing cells throughout the body with glutamate for metabolic purposes. The high-affinity glutamate transporters SLC1A1, SLC1A2, SLC1A3, SLC1A6, and SLC1A7 protect the CNS from glutamate-induced neurotoxicity. Glutamate transporters not only play a key role in the central nervous system by keeping extracellular levels below neurotoxic levels but also in peripheral tissues. For example, they contribute to nitrogen metabolism and inter-organ glutamine flux. In the central nervous system, glutamate transporters are found to be involved in neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis. The glutamate transporter also plays a key role in neuronal damage associated with ischemia. These findings make glutamate transporters potential drug targets.
Fig.1 Membrane topology and transport mechanism model of mammalian glutamate transporters. (Kanai, 2013)
In mammals, the SLC1 family includes five high-affinity glutamate transporters and two neutral amino acid transporters. Here show the six members of the SLC1 family of solute carriers: three excitatory amino acid transporters (SLC1A1, SLC1A2 and SLC1A3), two neutral amino acid transporters (SLC1A4 and SLC1A5) and an excitatory amino acid transporter (SLC1A7). In humans, the five glutamate transporters possess 44-55% amino acid sequence identity with each other, while the two amino acid transporters show 57% identity with each other.
Aided by cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
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