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Research & Development Services

Overview Service Features FAQs Scientific Resources Related Services

Stem cells are non-specialized cells and they have the ability to become many different types of cells. Therefore, these cells play a key role in the body's healing process and the stem cell regenerative medicine which also as known as Stem Cell Therapy (SCT). Donor stem cells or induced pluripotent stem cells (iPSCs) are known to permanently overcome various disorders at both preclinical and early clinical trials. Creative Biolabs have the ability to provide stem cell-based therapeutics development. Since stem cells are vital to the development, growth, maintenance, and repair of brains, bones, muscles, nerves, blood, skin, and other organs, we provided disease-specific stem cells therapy services, iPSC-derived cells therapy services. Also, to fit the rapid growth of stem cell therapy around the world, our scientists are using stem cells to develop customized disease modeling and to facilitated new drugs discovery for clients worldwide.

Stem cell therapy development

Overview of Stem Cell Therapy Research & Development

Stem cell therapy research and development focuses on harnessing the potential of stem cells to treat a wide range of diseases and injuries. Stem cells, characterized by their ability to self-renew and differentiate into various cell types, hold promise for regenerative medicine and personalized treatment. In the lab, researchers study how these cells can be used to repair or replace damaged tissues, regenerate organs, and develop new therapeutic strategies for conditions like neurodegenerative diseases, heart disease, diabetes, and even cancer.

Key areas of focus in stem cell therapy research include:

  • Regenerative Medicine: Using stem cells to repair or replace damaged tissues and organs.
  • Disease Modeling: Creating cell-based models to study disease mechanisms and screen potential drugs.
  • Cell Therapy: Developing treatments where stem cells are transplanted into patients to treat specific conditions.
  • Gene Editing: Combining stem cell technology with tools like CRISPR to correct genetic defects at the cellular level.

The development of stem cell therapies also involves overcoming challenges like ensuring the safety of stem cell use, preventing immune rejection, and scaling up production for widespread clinical use.

Research & Development Services

Disease-specific stem cell therapy development

Generally, there are two categories of stem cells upon their sources. One is called early stem cells, also known as embryonic stem cells, which are derived from embryos at a developmental stage before the time of implantation which normally occurs in the uterus. These cells are self-replicating pluripotent cells that are potentially immortal. Another type of stem cells is mature stem cells. Unlike embryonic stem cells, these cells are undifferentiated totipotent or multipotent cells, which are found throughout the body after embryonic development, which multiply by cell division to replenish dying cells and regenerate damaged tissues. For example, the sources of embryonic stem cells (ESC) are blastula and skin fibroblasts, these two types of cells can differentiation into cardiomyocytes. It treats cardiovascular disease via a direct contribution to contractility and remodeling of electrical properties. Also, the mesenchymal stem cells (MSC) can be derived from bone marrow or fat cells. The mechanism of treatment is through paracrine effects, the endogenous stem cells activated. At Creative Biolabs, we provided disease-specific stem cells for various diseases.

Stem cell therapy development

iPSC-derived cell therapy development

Induced pluripotent stem cells (iPSCs) are a type of pluripotent stem cell which has properties similar to embryonic stem cells. Forced expression of defined transcription factors, including Oct4, Sox2, Klf4, and c-Myc can manipulate somatic cells back to pluripotent state. iPSCs hold great promise in the field of regenerative medicine. They can not only propagate indefinitely, but also represent a single source of every other cell types in the body. Unlike embryonic stem cells, each individual could have their own iPSCs cell line, which means that the risk of immune rejection can be avoided. Also, without controversy surrounding their use and ethical issues, the iPSCs can be mass industrial product and legal commercial use. At Creative Biolabs, we provided iPSC derived immune cell therapy and iPSC derived stem cell therapy services. Please feel free to inquire to discuss your unique needs with us.

Stem cell therapy development

Stem cell facilitated drug discovery

Based on gene variation, hereditary state, and even the telomere and telomerase status of individual patients, the stem cells technology provides a means to obtain the required research materials for disease modeling. For individual disease pathogenesis study, we provide stem cell-based disease modeling service which involves the nervous system, blood system, cardiovascular, diabetes, liver diseases, as well as various genetic diseases. To meet the need of drug screening, drug safety testing, and even the individualized treatment plan decision, our stem cell-based drug discovery services accommodate you with a customized solution.

Stem cell therapy development

Please feel free to contact us for more professional consultation.

Service Features

We offer comprehensive and advanced services designed to accelerate your research and innovation in the field. Our R&D service features state-of-the-art technologies, specialized expertise, and customized solutions tailored to meet the specific needs of academic and pharmaceutical research teams. All our services are strictly for research use only, with the goal of driving scientific discovery and development in the area of regenerative medicine, disease modeling, and therapeutic interventions.

Key features of our service:

  • Custom differentiation protocols
  • Stem cell engineering and gene editing capabilities
  • Personalized disease modeling
  • High-throughput screening and drug testing
  • Comprehensive assays and characterization
  • Scalable cell expansion and banking
  • Consulting and custom R&D projects

By choosing our stem cell therapy research and development services, you gain access to world-class expertise, innovative technologies, and custom-tailored solutions to advance your research in stem cell biology and regenerative medicine.

FAQs

  • Q: Can your stem cell research services support therapeutic applications for specific diseases or conditions?
    A: Yes, we provide customized stem cell research solutions targeted at specific therapeutic applications, such as neurodegenerative diseases, cardiovascular disorders, musculoskeletal conditions, and more. By focusing on disease-specific models, we help researchers evaluate the efficacy and safety of stem cell therapies in preclinical stages, offering comprehensive data that facilitates future clinical translations.
  • Q: What support do you offer in preclinical testing of stem cell therapies?
    A: We provide extensive support in preclinical testing, from developing disease models to conducting in vitro and in vivo studies. Our services include efficacy testing, toxicology assessments, and biodistribution analysis. By integrating advanced imaging and molecular techniques, we help evaluate how stem cell therapies interact with disease environments, providing detailed insights into therapeutic potential and safety.
  • Q: Can you assist with the scale-up production of stem cells for larger research studies?
    A: Yes, we offer services for scaling up stem cell production to meet the needs of larger research projects. Whether you're conducting extensive in vitro testing or preparing for in vivo models, we can expand cell cultures to ensure you have a sufficient supply of high-quality stem cells. We use bioreactors and advanced culturing techniques to maintain cell viability and consistency during scale-up.
  • Q: How long does a typical stem cell research and development project take from start to finish?
    A: The timeline for stem cell research and development projects varies depending on the complexity and scope of the project. Typically, smaller-scale research projects can take between 3 to 6 months, while larger, more intricate projects, such as disease modeling or preclinical testing, may take 6 to 12 months or longer. We work closely with clients to establish realistic timelines and provide regular updates throughout the project.
  • Q: What kind of data do you provide?
    A: We deliver comprehensive data reports, including detailed experimental protocols, raw data, and analysis. Depending on your specific needs, we can provide information on stem cell characterization, differentiation markers, and functional assays. Additionally, we offer real-time progress reports and final study reports with full documentation, ensuring transparency and reproducibility of your research outcomes.

Scientific Resources

References

  1. Fortier, L. (2005). Stem Cells: Classifications, Controversies, and Clinical Applications. Veterinary Surgery, 34(5), pp.415-423.
  2. Rao, M. (2012). Stem cells and regenerative medicine. Stem Cell Research & Therapy, 3(4), p.27.
  3. Bae, K., Kim, S., Park, S., Jeong, A., Lee, H., & Lee, J. et al. (2014). Identification of Lactoferrin as a Human Dedifferentiation Factor Through the Studies of Reptile Tissue Regeneration Mechanisms. Journal Of Microbiology And Biotechnology, 24(6), 869-878. doi: 10.4014/jmb.1402.02009.

For Research Use Only. Not For Clinical Use.