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IgM

Human IgM (immunoglobulin M) is a pentameric, glycosylated protein of 900 kDa that constitutes 5-10% of the total immunoglobulins in serum. Because of its large size, the majority of IgM remains intravascular. IgM is produced in the primary immune response and is particularly effective in complement activation. The fact that IgM has 10 antigen binding sites gives it high affinity for micro-organisms with repeating antigenic units, such as capsular carbohydrate antigens, on the bacterial surface. Decreased serum IgM levels are unusual and almost always associated with significant disease.

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