Close

Transient Receptor Potential Channel Mucolipin Family

The transient receptor potential channel mucolipin (TRPML) is a subfamily of channel proteins within the transient receptor potential (TRP) superfamily of cation channels. Like other members of the TRP family, TRPMLs have six transmembrane domains and intracellular N- and C-termini (relatively short tails compared to other members). To date, three distinct proteins are known and designated TRPML1, TRPML2, and TRPML3. They are all localized to endo-lysosomes, although when overexpressed in heterologous systems, TRPML3 is found on the plasma membrane. Studies have suggested that members of the TRPML family are implicated in various membrane and protein sorting mechanisms along endo-lysosomal pathways. Furthermore, TRPML channels appear to be prominent lysosomal metal transporters.

Here, we have described in details of members of the transient receptor potential channel mucolipin family, which includes mucolipin-1, mucolipin-2, and mucolipin-3. To learn more detailed information, please click the links below.

Human TRPML Members
MCOLN1 MCOLN2 MCOLN3

With the help of our advanced Magic™ membrane protein production platform, Creative Biolabs is committed to offering various target membrane protein products in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.

Magic™ membrane protein production platform – Creative Biolabs

Furthermore, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches such as hybridoma technology, phage display technology. We also present DNA immunization service for anti-membrane protein antibody development. To get more detailed information, please feel free to contact us.


All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

Online Inquiry
CONTACT US
USA:
Europe:
Germany:
Call us at:
USA:
UK:
Germany:
Fax:
Email:
Our customer service representatives are available 24 hours a day, 7 days a week. Contact Us
© 2024 Creative Biolabs. | Contact Us