Chitosan (VAdv-Ly0024)
Chitosan, the deacetylated derivative of chitin, a NLRP3 inflammasome inducer.
Molecular Weight
60-120 kDa
Specificity
Th1/Th2 response
Endotoxin
Lower than 5 EU/mg.
Storage
Store at 2 to 8°C.
Introduction
Chitosan, derived from chitin deacetylation found in crustacean exoskeletons and fungal cell walls, has multiple biomedical applications. It serves as a drug delivery agent and an adjuvant by stimulating the immune system. Chitosan activates the NLRP3 inflammasome, leading to increased IL-1β production. In vaccine studies, it induces a balanced Th1/Th2 immune response.
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