Human CD33 Protein (Asp 18-His 259) [His] (VAng-2720Lsx)
Human Siglec-3 (CD33) protein, His tag, was expressed in human 293 cells. (Uniprot ID: AAH28152.1)
Datasheet
Specifications
Source
HEK293 cells
Target
CD33
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
PBS, pH 7.4.
Purity
> 95% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
CD33 is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells. The extracellular portion of this receptor contains two immunoglobulin domains (one IgV and one IgC2 domain), placing CD33 within the immunoglobulin superfamily. The intracellular portion of CD33 contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that are implicated in inhibition of cellular activity. It is the target of gemtuzumab ozogamicin, an Antibody-drug conjugate for the treatment of patients with acute myeloid leukemia.
Alternative Names
CD33, SIGLEC3, gp67
Related Product
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
