Pepsinogen II Antigen (VAng-Cr3888)
Pepsinogen II Antigen, Host/Source: Human Stomach. The purity is ≥90% by SDS-PAGE.
Datasheet
Specifications
Source
Human Stomach
Target
Pepsinogen II
Type
Tumor Antigens
Applications
ELISA, WB, Controls.
Formulation
Lyophilized.
Purity
≥ 90% pure by SDS-PAGE.
Storage
Store at -20°C.
Antigen Information
Introduction
Pepsinogen II is one of 4 aspartic proteinases: PG I, PG II, Cathepsin E and D. Pepsinogen II is produced primarily in the Oxyntic gland mucosa of the stomach, the gastric antrum and the duodenum. It is secreted mainly into the gastric lumen and into circulation. Pepsinogen II has little or no biological activity but in acid is converted to the active enzyme Pepsin which exhibits proteolytic actions. Unlike Pepsinogen I, Pepsinogen II is not normally found in the urine. Patients with pernicious anemia have low to non-detectable levels of Pepsinogen I but normal levels of Pepsinogen II. Pepsinogen II levels are slightly elevated in gastric ulcer. Patients with Zollinger-Ellison's syndrome exhibit greatly elevated levels.
Alternative Names
PGII
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