Pertussis Toxin (PT) Protein (VCar-Ly016)
A virulence factor, contains a high concentration of PT protein.
Source
Bordetella pertussis
Target
Binds to most cultured mammalian cells and targets specific G protein.
Applications
Inhibiting the ability of the G protein to function in signaling pathways.
Introduction
Pertussis toxin (PT) is a protein-based AB5-type exotoxin produced by Bordetella pertussis. It is a multi-subunit toxin which can bind to most cultured mammalian cells and targets specific G protein, inhibiting the ability of the G protein to function in signaling pathways. PT has been used to stimulate experimental autoimmune diseases in rodent models, such as experimental auto immune encephalitis (EAE). It was widely used as a biochemical tool to ADP-ribosylate GTP-binding proteins. In addition, it has also become an essential component of new acellular vaccines.
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