Recombinant Human E-Cadherin Protein (aa 1-709) [His] (VAng-Cr3960)
Recombinant Human E-Cadherin Protein (Met1-Ala709) fused with a His tag at C-terminus was expressed in Baculovirus-Insect Cells, with a molecular weight of 77.2 kDa. (Accession ID: NP_004351.1)
Datasheet
Specifications
Source
Human
Target
E-Cadherin
Type
Tumor Antigens
Applications
ELISA.
Formulation
Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 10% glycerol, pH 7.4.
Purity
> 90% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
E-Cadherin is a classical member of the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. Mutations are correlated with gastric, breast, colorectal, thyroid, and ovarian cancers. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells, and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. E-cadherin (epithelial) is the most well-studied member of the cadherin family. It consists of 5 cadherin repeats (EC1 - EC5) in the extracellular domain, one transmembrane domain, and an intracellular domain that binds p120-catenin and beta-catenin.
Alternative Names
CDH1; Arc-1; CD324; CDHE; ECAD; LCAM; UVO; cadherin 1; BCDS1
Related Product
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
