Recombinant Rat B7-H3 Protein (aa 29-248) (Yeast) (VAng-3492Lsx)
Recombinant Rat B7-H3 (CD276), expressed in Yeast. (Uniprot ID: Q8VE98)
Datasheet
Specifications
Source
Yeast
Target
B7-H3
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
PBS, pH 7.4.
Purity
> 95% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
B7-H3 is a human protein encoded by B7-H3 gene. It is an immune checkpoint molecule, is expressed by some solid tumours and is the target of anticancer candidates such as MGA271. It belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this protein.
Alternative Names
B7-H3, CD276, B7 homolog 3
Related Product
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
