Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsVasopressin (VP) receptors are receptors that mediate the functions of arginine vasopressin (AVP). The VP receptors are members of the G-protein coupled receptor (GPCR) superfamily, consisting of seven hydrophobic transmembrane α helices joined by an extracellular N-terminal domain and a cytoplasmatic C-terminal domain. Based on the second messenger to which they are coupled, VP receptors are classified into V1a, V1b, and V2 subtypes. The V1a and V1b receptors are linked to the phosphoinositol signaling pathway via Gaq/11 GTP-binding proteins that activate phospholipase C activity, with intracellular calcium acting as the second messenger. In contrast, V2 receptors are linked to the adenylate cyclase signaling pathway via Gs-binding proteins, with intracellular cAMP acting as the second messenger.
Moreover, these subtypes differ in localization and function. V1a receptors are widely distributed and V1b receptors are mainly expressed in the anterior pituitary and the brain. V2 receptors are expressed in the kidney tubule, in fetal lung tissue and lung cancer. V1a receptors mediate vasoconstriction, myocardial hypertrophy, platelet aggregation, glycogenolysis, and uterine contraction. V1b receptors mediate corticotrophin (ACTH) release while V2 receptors mediate free water reabsorption and maintain water homeostasis. Due to their involvement in a large spectrum of physiologic processes, antagonists of VP receptors have been developed for the treatment of diseases, such as hyponatremia.
Here, we present an introduction of different subtypes of vasopressin receptors, including the structure, signaling pathways, tissue distribution, functions, and applications.
In order to facilitate the basic understanding of the biology of these proteins and to aid future drug design, Creative Biolabs provides our robust and versatile Magic™ Membrane Protein Production Platform, to obtain purified, stabilized, and functional membrane proteins of different formats. It is accomplished by the use of different reconstitution systems, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, and polymers.
Furthermore, as a leading company in antibody development, Creative Biolabs also provides antibody discovery services against membrane proteins using various methods. Please see Magic™ membrane protein antibody discovery. We also present DNA immunization service for anti-membrane protein antibody development. If you are interested in discovering novel membrane protein antibodies, please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
