Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsATP-binding cassette (ABC) transporters form a large protein family. They bind and hydrolyze ATP, and utilize the energy of ATP hydrolysis to mediate the translocation of a wide variety of substances across cellular membranes. Forty-eight human ABC transporters have been identified and subdivided into seven phylogenic groupings, subfamily ABCA through to ABCG. The human ABCA subfamily is composed of 12 members, ABCA1-10, and ABCA12-13. Among these, ABCA1 plays a key metabolic role in reverse cholesterol transport from peripheral tissues to the liver, and in HDL synthesis. ABCA4 is a putative transporter of retinoids in rod cells and ABCA2 is a lysosome-associated transporter found in brain oligodendrocytes. Human ABCA3 is expressed in the lung alveolar type II cells, while ABCA7 is expressed mainly in the spleen and in hematopoietic tissues. ABCA12 appears to be essential for normal development of the skin. These transporters have been discovered to be associated with different diseases. The other members, ABCA5, 6, 8, 9, and 10, are found to be organized into a head to tail cluster of chromosomes on chromosome 17q24.
Here, we give an introduction of part of the human ABC subfamily A members focusing on their structure, tissue distribution, physiological roles and functions, as well as recent findings. Some of these transporters are well-characterized but the properties of the others are required to be further elucidated in the future.
When taking up the task of studying membrane proteins in vitro, a challenge comes up, that is the difficulty of finding appropriate approaches to reconstitute these proteins while ensuring correct functionality and proper folding. Aided by our cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to utilize the current state-of-the-art methodologies of membrane protein preparation in biomimetic-supported systems, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, and polymers.
Moreover, as a leading company specialized in antibody discovery and development, we have developed our Magic™ membrane protein antibody discovery platform and equipped with advanced antibody development technologies. We also present DNA immunization service for anti-membrane protein antibody development. Whether you are interested in membrane protein preparation or the discovery of antibodies against these antigens, you can contact us to learn more about our services.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
