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The vector of anti-BCMA chimeric antigen receptor (CAR) is constructed for the engineering of T cell to target human BCMA. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-BCMA antibody linked to CD137 (4-1BB) and CD3ζ signaling domains. And the vector product was designed for the treatment of multiple myeloma.
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CAR Construction :
Fig.1 Dual staining byJ6M0-PerCP-Cy5.5 and CD38-PE Cy7 was done in MM1S and CD1381 patient MM cells. Immunostaining with J6M0 mAb (solid line) or isotype cont Immunostaining with J6M0 mAb (solid line) or isotype control human IgG (iso IgG1,dashed line) was performed in CD1381 cells from additional MM patients. Tai, Y. T., Mayes, P. A., Acharya, C., Zhong, M. Y., Cea, M., Cagnetta, A., ... & Anderson, K. C. (2014). Novel anti–B-cell maturation antigen antibody-drug conjugate (GSK2857916) selectively induces killing of multiple myeloma. Blood, The Journal of the American Society of Hematology, 123(20), 3128-3138. |
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CAR Construction :
Fig.2 J6M0-mcMMAF selectively inhibits MM cell viability and colony formation via caspase 3/7-dependent apotosis. All measurements were performed in triplicate. Tai, Y. T., Mayes, P. A., Acharya, C., Zhong, M. Y., Cea, M., Cagnetta, A., ... & Anderson, K. C. (2014). Novel anti–B-cell maturation antigen antibody-drug conjugate (GSK2857916) selectively induces killing of multiple myeloma. Blood, The Journal of the American Society of Hematology, 123(20), 3128-3138. |
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CAR Construction :
Fig.3 BCMA expression of patient samples by flow cytometry with J6M0-wtFc PE showing MFIr for individual patients. BCMA expression by flow cytometry. Lee, L., Bounds, D., Paterson, J., Herledan, G., Sully, K., Seestaller‐Wehr, L. M., ... & Yong, K. L. (2016). Evaluation of B cell maturation antigen as a target for antibody drug conjugate mediated cytotoxicity in multiple myeloma. British journal of haematology, 174(6), 911-922. |
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