Modified Cytokine Receptor-CIK Devlopment Service

The Necessary of Efficient CIK Therapeutics Development

Cytokine-induced killer (CIK) cells represent a novel immunotherapeutic strategy employing modified T cells. These cells demonstrate potent cytotoxicity against various malignancies, including hematological and solid tumors, while exhibiting a favorable safety profile. While CIK cell therapy offers significant potential in cancer treatment, its effectiveness can be compromised by the immunosuppressive tumor microenvironment. Ongoing research aims to enhance CIK cell efficacy and overcome these limitations to improve patient outcomes.

The Benefits of CIK Cells

• Easy Expansion: CIK cells can be readily expanded from peripheral blood lymphocytes, making them a readily accessible source for immunotherapy.
• Broad Anti-tumor Activity: CIK cells exhibit a wide range of anti-tumor activity, targeting both cancer cells and cancer stem cells.
• Reduced Side Effects: Compared to other immunotherapies, CIK cell treatment is typically well tolerated and has few adverse effects.
• Enhanced Immune Response: CIK cells can stimulate the patient's immune system, leading to a more robust anti-tumor response.
• Synergy with Other Therapies: To maximize their effectiveness, CIK cell therapy can be coupled with other therapies such as radiation or chemotherapy.

Fig.1 CIK cells as an alternative to overcome the limitation faced by CAR-T.¹

Modified Cytokine Receptor-CIK Development Service at Creative Biolabs

Creative Biolabs provides a cost-effective modified cytokine receptor-CIK development service to aid in CIK research on anti-tumor efficacy enhancement. Our services encompass target selection, cell isolation, expansion, genetic modification, and characterization. We utilize advanced gene editing technologies and mRNA-based methods to introduce specific cytokine receptors into CIK cells, enabling precise control over their activation and proliferation.

Leveraging our extensive expertise in tumor biology, we offer a range of customizable cytokine receptor options to tailor CIK cells to specific tumor types. Our stringent quality control procedures ensure the safety and efficacy of the engineered CIKs. Additionally, we offer a variety of innovative CIK cell engineering strategies, including CAR-CIK, DC-CIK, and safety switch-integrated CIK, to further optimize their therapeutic potential. With our state-of-the-art platform, we are committed to delivering high-quality modified cytokine receptor-CIK cells to advance cancer immunotherapy.

Fig.2 Modified cytokine receptor-CIK development service process.

Customizable Cytokine Receptor Options

Modifying CIK cells with cytokine receptors is a promising strategy to enhance their anti-tumor activity and persistence. By introducing specific cytokine receptors into CIK cells, researchers are able to fine-tune their behavior, including their ability to migrate to tumor sites, proliferate, and effectively eliminate cancer cells. Here are some commonly used cytokine receptors for CIK cell engineering:

Fig.3 Tumor-specific cytokine receptors.

Our Service Features

• Extensive customizable cytokine receptor options.
• Wealthy experience in CIK research.
• Robust cell engineering platforms.
• Customized CIK engineering process.
• Further strategies on CIK engineering.
• State-of-the-art technologies incorporating.
• Accelerated timeline.

Frequently Asked Questions

Q1: What are the potential benefits of modified CIK cell therapy?

A1: Evidence has demonstrated that modified CIK cell therapy offers several potential advantages, including enhanced tumor targeting and infiltration, increased proliferation and persistence, improved cytotoxicity against cancer cells, and reduced side effects compared to traditional therapies.

Q2: How to ensure the quality and safety of modified CIK cells?

A2: Throughout the development process, we employ stringent quality control techniques to verify the quality and safety of modified CIK cells. This includes meticulous donor screening, strict adherence to aseptic techniques, the use of well-characterized and safe genetic modification methods, as well as comprehensive cell characterization from phenotypic and functional. In addition, we strictly adhere to Good Manufacturing Practices (GMP) guidelines during manufacturing and stringent release criteria for final product testing to further guarantee the safety and efficacy of these advanced immunotherapies.

If you are interested in our modified cytokine receptors-CIK development service, please don't hesitate to get in touch with us.

Reference

1. Cappuzzello, Elisa, et al. "How can Cytokine-induced killer cells overcome CAR-T cell limits." Frontiers in Immunology 14 (2023): 1229540. Distributed under Open Access license CC BY 4.0, without modification.