• One-Stop CAR-T Therapy Development
  • Biomarker Identification & Selection
  • ScFv Generation
  • CAR Design & Construction
  • CAR-T Gene Packaging & Delivery
  • Replication-Competent Virus Testing
  • CAR Cell In Vitro Assay
  • CAR-T Preclinical In Vivo Assay
  • IND Development for CAR-T Cell Therapy
  • GMP Production for CAR-T Products
  • CAR Clinical Trial
  • One-Stop Canine CAR-T Therapy Development
  • One-Stop mRNA CAR-T Therapy Development
  • TRAC-CAR-T Cell Development
  • Modular CAR-T Cell Generation
  • One-Stop Silence™ CAR-T Cell Development
  • Vaccine Boosting CAR-T Cell Therapy
  • STAb-T Cell Therapy Development
  • CAR-T Therapy Development in the Non-Cancer Field
  • Anti-HIV CAR Cell Therapy Development
  • T Cell Activity Modulator Discovery
  • T Cell Programming
  • Virus Specific T Cell (VST) Development
  • Antibody-Coupled T Cell Receptor (ACTR) Development
  • Organoid-induced hPSC-original T Cell Differentiation
  • γδ T Cell Engineering
  • CAR-T CDMO
• One-Stop TCR-T Therapy Development
  • TCR Biomarker Identification & Selection
  • TCR Generation & Optimization
  • TCR Design & Construction
  • TCR Gene Packaging & Delivery
  • TCR In Vitro Assay
  • TCR-T Preclinical In Vivo Assay
  • TCR Clinical Application
  • TCR Analysis
  • TCR Tetramerization Construction
  • ScFv-TCR T Cell Therapy Development
  • AbTCR Development
  • Bispecific TCR Development
  • CER Development
• One-Stop CAR-MA Therapy Development
• One-Stop CAR-NK Therapy Development
  • One-Stop CAR-NKT Therapy Development
  • One-Stop UniCAR-NK Therapy Development
  • iPSC-derived CAR-NK Therapy Development
  • One-Stop TCR-NK Therapy Development
  • NK Cell Genetic Engineering
  • NK Cell Expansion
• One-Stop CAR-B Therapy Development
• One-Stop CAR-Monocyte Therapy Development
• One-Stop Cytokine Release Syndrome (CRS) Management
• TCR-Like Antibody Development
  • MHC/Peptide Complex Production
  • TCR-Like Antibody Discovery
  • TCR-Like Antibody Affinity Characterization
  • TCR-Like CAR Construction & Evaluation
• In Vivo Cell Engineering Development
  • In Vivo CAR-T Cell Engineering
  • In Vivo B Cell Engineering
  • In Vivo CAR-NK Cell Engineering
  • In Vivo CAR-M Cell Engineering
• One-Stop Allogeneic Cell Therapy Development
  • Allogeneic CAR-T Therapy Development
  • Allogeneic TCR-T Therapy Development
  • Allogeneic CAR-NK Therapy Development
  • Allogeneic CAR/TCR Cell Design & Engineering
  • Other Allogeneic Cell Therapy Development
• TCR/CAR/Antigen-Engineered Tregs Development
  • CAR-Treg Development
• Cancer Vaccine Development
  • Cancer Vaccine Discovery
  • Cancer Vaccine Engineering
  • Cancer Vaccine Analytical Characterization
  • Cancer Vaccine In Vivo Assessment
  • Cancer Vaccine GMP Manufacturing
  • Dendritic Cell Vaccine Development
• Immune Genotyping
  • HLA Typing
  • KIR Typing
  • HLA Testing
  • Dog DLA Genotyping
  • Guinea Pig GPLA Genotyping
  • Mouse H2 Genotyping
  • Rabbit RLA Genotyping
  • Rat RT1 Genotyping
  • Rhesus Macaque MHC Genotyping
• Other Services
  • Tumor-infiltrating Lymphocyte-based Antibody Discovery

NHP PBMC Model Development Service

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Due to their strong similarities to humans across physiologic, developmental, behavioral, immunologic, and genetic levels, non-human primate (NHP) peripheral blood mononuclear cells (PBMCs) are essential models for a wide spectrum of biomedical research. NHP PBMCs can serve to link the translational research between small animal models and humans. Creative Biolabs provides unparalleled access and customized services for researchers to propose cytokine release syndrome (CRS) management solutions. We offer NHP PBMC model products, establishement services as well as further cytokine detection and analysis services for worldwide clients.

Introduction

PBMCs are a subset of leukocytes, which are integral components of the body's immune system that fight disease. PBMCs consist of a mixture of monocytes and lymphocytes (B cells, T cells, and NK cells) and are isolated from peripheral whole blood via density gradient centrifugation and red blood cell lysis.

PBMCs of NHP are used because of the similarities of these animals to humans in terms of physiology, neuroanatomy, reproduction, cognition, development and social complexity. The close phylogenetic relationship of NHP to humans also makes these animals excellent models for the study of CRS. These similarities between NHP and humans suggest that there is greater validity of the data obtained from primate PBMC models compared to other animal cell models, and experiments conducted using these models might address questions that cannot be addressed using other species.

Services

The PBMCs of NHP such as African Green Monkey, Baboon, Beagle, Cebus, Cynomolgus monkey, Marmoset, Rhesus monkey, Squirrel monkey are available as pooled or individual samples, with either sex as an option. Used for a variety of applications, PBMCs are frequently utilized in drug discovery/development, assay validation/development, and other immunology applications. Creative Biolabs offers isolated PBMCs from NHPs and can provide cytokine release assay (CRA) assay services with the help of our featured NHP PBMCs products. Flow cytometry analysis of the NHP PBMCs will be conducted to demonstrate the expression of cell surface cytokine biomarkers. Further in vitro CRA service andin vitro cytotoxicity analysis service are also available.

Features of Our NHP PBMC Model

• Isolated from peripheral blood collected from a variety of anticoagulants
• Available in custom formats and aliquot sizes
• Rigorous QC ensures consistent, reliable cell lots

If you are interested in our NHP PBMCs model for CRS research, please feel free to contact us to find suitable products and services to support your specific program.