Mouse Anti-Human Factor B Monoclonal Antibody (TJL-66) [iFluor® 488](Cat#: CTMM-0322-JL335)
This product is an iFluor® 488 conjugated anti-Human Complement Factor B Monoclonal antibody (TJL-66) generated from the Mouse. The antibody can be used for WB, IF, IHC, FCM.
Summary
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Specifications
| Clonality |
Monoclonal |
| Clone |
TJL-66 |
| Host Animal |
Mouse |
| Isotype |
IgG1 Kappa |
| Immunogen |
Human Complement Factor B, a.a. 426-520 |
| Species Reactivity |
Human |
| Applications |
WB; IF; IHC; FCM |
| Application Notes |
WB: 1:100-1:1000
IF: 1:50-1:500
IHC: 1:50-1:500 |
| Specificity |
This antibody reacts with Human Complement Factor B. |
| Purity |
≥95% as determined by SDS-PAGE |
| Conjugation |
iFluor® 488 |
| Format |
Liquid |
| Size |
200 µg |
| Storage |
Store in dark at 4°C. Do Not Freeze. |
| Type |
Primary Antibody |
Target
| Target Name |
Factor B |
| Alternative Names |
B-Factor, Properdin; Properdin Factor B; C3/C5 Convertase; Glycine-Rich Beta-Glycoprotein; Glycine-Rich Beta Glycoprotein; C3 ProacceleRator; C3 Proactivator; EC 3.4.21.47; BF; FB; BFD; GBG; CFAB; CFBD; PBF2; AHUS4; FBI12; H2-Bf; ARMD14 |
| Gene ID |
629 |
| UniProt ID |
P00751 |
Information
| Introduction |
Complement factor B is a protein that in humans is encoded by the CFB gene. This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease that associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the prolifeRation of preactivated B lymphocytes, while Ba inhibits their prolifeRation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 12. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
