Mouse Anti-Human Factor I Monoclonal Antibody (CTJS-108)(Cat#: CTA-638)
This product is an unconjugated anti-Human Complement Factor I Monoclonal antibody (CTJS-108) generated from the Mouse. The antibody can be used for ELISA.
Summary
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Specifications
| Clonality |
Monoclonal |
| Clone |
CTJS-108 |
| Host Animal |
Mouse |
| Isotype |
IgG2b |
| Immunogen |
Complement Factor I purified from Human blood |
| Species Reactivity |
Human |
| Applications |
ELISA |
| Application Notes |
ELISA: 1 µg/mL
The optimal working dilutions should be determined by the end user. |
| Specificity |
This antibody reacts with Human Complement Factor I. |
| Purity |
≥95% as determined by SDS-PAGE |
| Conjugation |
Unconjugated |
| Format |
Liquid |
| Size |
100 µg |
| Storage |
Store at 4°C for short term. Store at -20°C for long term. Avoid freeze-thaw cycle. |
| Type |
Primary Antibody |
Target
| Target Name |
Factor I |
| Alternative Names |
Complement Factor I; Konglutinogen-Activating Factor; C3B/C4B Inactivator; C3b-Inactivator; C3b-INA; Complement Control Protein Factor I; Complement Factor I Heavy Chain; Light Chain Of Factor I; Complement Component I; I Factor (Complement); CFI |
| Gene ID |
3426 |
| UniProt ID |
P05156 |
Information
| Introduction |
Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha-chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins. Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces. The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired complement activation, while in apoptotic cells or microbes, the absence of such cofactors leads to C3b-mediated complement activation and subsequent opsonization. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
