Native Human Complement Factor I Protein(Cat#: CTP-457)
This product is a Human factor I protein purified from normal human serum. Factor I is a naturally glycosylated serine protease which cleaves and inactivates C3b and C4b. It is highly specific but inactive without a cofactor such as the soluble factor H and C4b binding protein (C4BP).
Summary
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Specifications
| Specie Reactivity |
Human |
| Target |
Factor I |
| Molecule Mass |
88 kDa |
| Purity |
>95% determined by SDS-PAGE |
| Endotoxin |
<1.0EU per 1µg (determined by the LAL method) |
| Formulation |
10 mM sodium phosphate, 145 mM NaCl, pH 7.2 |
| Applications |
Functional Assays |
| Product Form |
Frozen liquid |
| Storage |
Store at -20°C/-80°C. Avoid freeze-thaw cycles. |
Protein Information
| Introduction |
Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha-chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins. Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces. The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired complement activation, while in apoptotic cells or microbes, the absence of such cofactors leads to C3b-mediated complement activation and subsequent opsonization. |
| Alternative Names |
Complement Factor I; Konglutinogen-Activating Factor; C3B/C4B Inactivator; C3b-Inactivator; C3b-INA; Complement Control Protein Factor I; Complement Factor I Heavy Chain; Light Chain Of Factor I; Complement Component I; I Factor (Complement); CFI |
| Gene ID |
3426 |
| UniProt ID |
P05156 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
