Recombinant Rat Complement Factor I Protein(Cat#: CTP-119)
This product is a 67.3 kDa recombinant rat Complement Factor I protein with a N-terminal tag or C-terminal tag expressed in the E. Coli or Yeast or Baculovirus or Mammalian Cell.
Summary
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Specifications
| Expressed Host |
E. Coli or Yeast or Baculovirus or Mammalian Cell |
| Specie Reactivity |
Rat |
| Target |
Factor I |
| Molecule Mass |
67.3 kDa |
| Purity |
>85% (SDS-PAGE) (lot specific) |
| Endotoxin |
<1.0EU per 1µg (determined by the LAL method) |
| Formulation |
Tris-based buffer, 50% glycerol |
| Product Form |
Liquid containing glycerol |
| Storage |
Store at -20/-80°C. Aliquot to avoid repeated freezing and thawing. |
Protein Information
| Introduction |
Complement factor I is a Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha-chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins. Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces. The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired complement activation, while in apoptotic cells or microbes, the absence of such cofactors leads to C3b-mediated complement activation and subsequent opsonization. |
| Alternative Names |
Complement factor I; C3B/C4B inactivator; FI |
| Gene ID |
79126 |
| UniProt ID |
Q9WUW3 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
